IMPACT OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs) DURING PREGNANCY AND LACTATION: A FOCUS ON SHORT AND LONG-TERM VASCULAR EFFECTS.

IMPACT OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs) DURING PREGNANCY AND LACTATION: A FOCUS ON SHORT AND LONG-TERM VASCULAR EFFECTS. Vascul Pharmacol. 2018 May 24;: Authors: Zullino S, Simoncini T Abstract SSRIs are the first choice for the treatment of mood disorders during pregnancy and lactation. Despite the known side effects, the benefits/risks balance suggests their use. Hypertensive disorders of pregnancy (HDP) and Intrauterine growth restriction (IUGR) are the main vascular effects of these drugs, with mechanisms that involves endothelial dysfunction in feto-placental system. These data are supported by animal models, even if preliminary findings are not yet adequately supported by molecular and clinical data. SSRIs. applications and mode of action. Nowadays selective serotonin reuptake inhibitors (SSRIs) are among the most used antidepressants in the treatment of major depressive and anxiety disorders. This class of drugs is also widely prescribed for panic disorders, obsessive-compulsive disorder (OCD), eating disorders and post-traumatic stress disorder (PTSD). The exact mechanism of action of SSRIs is unknown. However SSRIs are believed to increase the extracellular levels of the neurotransmitterserotonin by limiting its reuptake into the presynaptic cell, increasing the levels in the synaptic cleft available to bind the postsynaptic receptor. They have varying degrees of selectivity for the other monoamine transpor...
Source: Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Vascul Pharmacol Source Type: research