Reply to: Genotype-Phenotype Pancreatic Neuroendocrine Tumor Relationship in Multiple Endocrine Neoplasia Type 1 Patients: A 23 Year Experience at a Single Institution

We thank Dr Dreijerink for his thoughtful query regarding our findings of an association in MEN1 patients between the presence of a germline MEN1 exon 2 mutation and an increased risk of developing a pancreatic neuroendocrine tumor (PNET) and distant PNET metastases. We understand and agree that the roles of inactivating mutations (including nonsense and frameshift) versus missense mutations in these associations are potentially distinct and are potentially important to evaluate. Therefore, we provide the following post-hoc retrospective analyses to explore this hypothesis.

Source: Surgery - May 31, 2018 Category: Surgery Authors: Ioannis Christakis, Jeffrey E. Lee Tags: Letters to editor Source Type: research