Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p

Upregulated expression of autotaxin, a secreted phospholipase and phosphodiesterase enzyme, appears in malignant disease. The identification of a circulating miRNA signature should distinguish autotaxin-mediated disease and also elucidate unknown molecular mechanisms that rationalize its malignant potential. Using female transgenic ‘AT-ATX’ mice, whereby human wild-type autotaxin is expressed in liver under the control of the alpha-1 antitrypsin promoter, transgenic animals express augmented autotaxin in circulation and a percentage develop tumors.
Source: Cancer Letters - Category: Cancer & Oncology Authors: Tags: Original Articles Source Type: research