Lower glutamate level in temporo-parietal junction may predict a better response to tDCS in schizophrenia

Auditory hallucinations are highly distressing and functionally impairing to patients with schizophrenia. Brain areas which show activation during auditory hallucination periods have been targeted for neuromodulation treatment, such as the auditory cortex or temporo-parietal junction (TPJ) (Brunelin et al., 2012). Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique which uses weak electric currents to modulate targeted brain areas. Some studies have shown that tDCS may be useful in reducing psychotic symptoms such as auditory hallucinations by suppressing hyperactivity of the temporal lobe (Brunelin et al., 2012; Mondino et al., 2016).
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the editor Source Type: research