Watershed Microinfarct Pathology and Cognition in Older Persons

Brain microinfarcts are common in aging and are associated with cognitive impairment. Anterior and posterior watershed border zones lie at the territories of the anterior, middle, and posterior cerebral arteries, and are more vulnerable to hypoperfusion than brain regions outside the watershed regions. However, little is known about microinfarcts in these regions and how they relate to cognition in aging. Participants from the Rush Memory and Aging Project (MAP), a community-based clinical-pathologic study of aging, underwent detailed annual cognitive evaluations.

Source: Neurobiology of Aging - May 30, 2018 Category: Neuroscience Authors: A. Kapasi, S.E. Leurgans, B.D. James, P.A. Boyle, Z. Arvanitakis, S. Nag, D.A. Bennett, A.S. Buchman, J.A. Schneider Source Type: research