The contribution of small vessel disease to subtypes of Alzheimer ’s disease: a study on cerebrospinal fluid and imaging biomarkers

We investigated whether subtypes of Alzheimer ’s disease (AD), i.e. typical, limbic-predominant, hippocampal-sparing, and minimal atrophy AD, had a specific signature of small vessel disease and neurodegeneration. 423 clinically diagnosed AD patients were included (161 typical, 121 limbic-predominant, 70 hippocampal-sparing, 71 minimal atroph y). 156 fulfilled a biomarkers-based AD diagnosis. White matter hyperintensities (WMH) and cerebral microbleeds (CMB) had the highest prevalence in limbic-predominant AD, and the lowest prevalence in minimal atrophy AD.

Source: Neurobiology of Aging - May 30, 2018 Category: Neuroscience Authors: Daniel Ferreira, Sara Shams, Lena Cavallin, Matti Viitanen, Juha Martola, Tobias Granberg, Mana Shams, Peter Aspelin, Maria Kristoffersen-Wiberg, Agneta Nordberg, Lars-Olof Wahlund, Eric Westman Source Type: research