Norepinephrine augmented in vitro growth of uropathogenic E. coli in type 2 diabetes mellitus and its suppression by silodosin (alpha blocker)

Norepinephrine is secreted under conditions of stress in humans. The ability of bacteria to sense mammalian hormone may have a role in propagation of infection. The present study investigated the effect of norepinephrine on in vitro growth of uropathogenic E.coli (UPEC) and the effect of silodosin on norepinephrine-induced changes. The spot urine samples were collected from 56 individuals (14 diabetic patients with UTI, 14 diabetic without UTI, 14 non-diabetic UTI and 14 healthy volunteer controls) for the measurement of urinary norepinephrine concentrations.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research