Long-term use of selective digestive decontamination in an ICU highly endemic for bacterial resistance

We examined whether long-term use of selective digestive tract decontamination (SDD) was effective in reducing intensive care unit (ICU)-acquired infection and antibiotic consumption while decreasing colistin-...
Source: Critical Care - Category: Intensive Care Authors: Tags: Research Source Type: research

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Conclusions: Orbital sarcoidosis is seen in a high TB endemic country like India and is definitely underreported. PMID: 32073939 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
We report a case of a fatal Strongyloides stercoralis hyperinfection syndrome (SHS) in a migrant from Kenya, who had been living in Germany for three decades. A short-course oral steroid treatment for Chronic Obstructive Lung Disease (COPD) exacerbation had been administered four weeks prior to the presentation. The initial clinical and radiological findings suggested a mechanical small bowel obstruction as a cause of ileus. Our case highlights the importance of maintaining a high index of suspicion for strongyloidiasis in patients from endemic areas even years after they left the country of origin. It demonstrates that ev...
Source: Parasitology International - Category: Parasitology Source Type: research
CONCLUSION: N1 showed moderate trypanocidal and promising immunomodulatory activities, and its use in combination with benznidazole and/or anti-arrhythmic drugs as well as the efficacy of its alternative formulations must be investigated in the near future. PMID: 32074167 [PubMed - as supplied by publisher]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
nata Hoffmann Cowpox virus (CPXV) belongs to the genus Orthopoxvirus in the Poxviridae family and is endemic in western Eurasia. Based on seroprevalence studies in different voles from continental Europe and UK, voles are suspected to be the major reservoir host. Recently, a CPXV was isolated from a bank vole (Myodes glareolus) in Germany that showed a high genetic similarity to another isolate originating from a Cotton-top tamarin (Saguinus oedipus). Here we characterize this first bank vole-derived CPXV isolate in comparison to the related tamarin-derived isolate. Both isolates grouped genetically within the provisio...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Mar ília Fonseca Rocha, Érika Monteiro Michalsky, Fabiana de Oliveira Lara-Silva, Josiane Lopes Valadão, João Carlos França-Silva, Letícia Cavalari Pinheiro, Joel Fontes de Sousa, Ronaldo Cardoso dos Santos, Marcelo Dias Soares, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias Visceral leishmaniasis (VL) is a neglected tropical disease, caused byLeishmania (Kinetoplastida, Trypanosomatidae) species. In Brazil, the transmission of this parasite essentially occurs through the bite ofLutzomyia longipalpis (Diptera: Psychodidae: Phlebotominae) previously infected withLeishmania ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ConclusionA few scattered cases still can be seen in post-elimination era and some kind of leprosy control program is still necessary. Government commitments including adequate financial security and strong policy support are vital. Comprehensive case-finding measures including health promotion, personnel training, reward-offering, with an emphasis on former high or middle endemic areas, are necessary to improve early presentation of suspected cases and to increase suspicion and encourage participation of all relevant medical staff. Symptom surveillance based on a powerful transfer center may play an important role in the ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Aparna Palit, Hemanta Kumar KarIndian Journal of Dermatology, Venereology, and Leprology 2020 86(2):115-123 With the worldwide implementation of WHO multidrug therapy in the 1980s, the global burden of leprosy has decreased. However, the annual new case detection rate around the world has remained nearly static over the past decade with India, Brazil, and Indonesia contributing the majority of these new cases. This has been attributed to the ongoing transmission of Mycobacterium leprae from existing untreated cases and partly to the intensive new case detection programs operative in endemic areas. The WHO has called for a...
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research
Visceral leishmaniasis (VL) is a public health threat for several tropical countries, including Brazil (Antinori et al., 2012; Burza et al., 2018). In the past two decades, Brazil witnessed changes in the epidemiology of VL, which moved from a rural endemic in poorest Northeastern States to an urban emerging disease spreading into the more developed Southeastern Region (Conti et al., 2016; Martins-Melo et al., 2018). In this new setting, the epidemics of VL and AIDS intertwined (Lindoso et al., 2014; Leite de Sousa-Gomes et al., 2017; Lindoso et al., 2018).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Understanding the genetic basis for a phenotype is a central goal in biological research. Much has been learnt about bacterial genomes by creating large mutant libraries and looking for conditionally important genes. However, current genome-wide methods are largely unable to assay essential genes which are not amenable to disruption. To overcome this limitation, we developed a new version of "TraDIS" (transposon directed insertion-site sequencing) that we term "TraDIS-Xpress" that combines an inducible promoter into the transposon cassette. This allows controlled overexpression and repression of all gen...
Source: Genome Research - Category: Genetics & Stem Cells Authors: Tags: METHOD Source Type: research
(American Chemical Society) People living in Balkan farming villages along the Danube River have long suffered from a unique type of kidney disease known as Balkan endemic nephropathy. Recently, scientists linked the disorder to compounds from a local weed that could be taken up into food crops from the soil. Now, researchers reporting in ACS' journalEnvironmental Science&Technology have discovered that contaminated groundwater could be another important source of human exposure.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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