Blood cell disruption to significantly improve the Borrelia PCR detection sensitivity in borreliosis in humans

Lyme disease is the most frequently reported zoonotic tick-borne disease worldwide, and the number of infected humans is increasing. Lyme disease (or Lyme borreliosis) is an affection caused by the spirochete Borrelia burgdorferi, sensu lato. Lyme disease is also reported as a variety of misleading clinical symptomatologies. Infected patient ’s blood serology is the most currently test used for its diagnosis. However, serology has a low sensitivity, which ranges from 34% to 70%.Thus, there are numerous subsequent false-negative diagnoses despite an active clinical infection profile.

Source: Medical Hypotheses - April 15, 2018 Category: Biomedical Science Authors: Alexis Lacout, Yves Mone, Michel Franck, Pierre-Yves Marcy, Marie Mas, Francisco Veas, Christian Perronne Source Type: research