Of ignorance and blindness: The Lyme disease paradigm.

Of ignorance and blindness: The Lyme disease paradigm. Med Mal Infect. 2018 May 24;: Authors: Raoult D PMID: 29805049 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

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Conditions:   Glaucoma;   Vision Impairment and Blindness;   Cataract;   Diabetic Retinopathy;   Eye Diseases Interventions:   Behavioral: Enhanced Intervention Using Patient Navigators;   Other: Usual Care Sponsors:   Columbia University;   Centers for Disease Control and Prevention Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Augstburger E, Héron E, Abanou A, Habas C, Baudouin C, Labbe A Abstract Ischemic optic neuropathies are among the leading causes of severe visual acuity loss in people over 50 years of age. They constitute a set of various entities that are clinically, etiologically and therapeutically different. Anatomically, it is necessary to distinguish anterior and posterior forms. From an etiological point of view, the diagnosis of the arteritic form due to giant cell arteritis requires emergent management to prevent blindness and even death in the absence of prompt corticosteroid treatment. When this diagnosi...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Jake Ternent, 22, from Ludworth, Co Durham had resigned himself to going completely blind due to an inherited degenerative eye condition. However, pioneering gene therapy may reverse the damage.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Ahmad A, Ahsan H Abstract The review article focuses on free radicals and oxidative stress involved in ophthalmological diseases such as retinopathy, cataract, glaucoma, etc. Oxidative stress is considered as a key factor involved in the pathology of many chronic diseases including ophthalmic complication and inflammatory process. Oxidative stress and inflammation are closely related pathophysiological processes and are simultaneously found in many pathological conditions. The free radicals produced oxidize cellular components such as lipids and phospholipids leading to lipid peroxidation and trigger the o...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This morning, I awoke to find that I had been copied on dozens of Twitter message exchanges among several people who were discussing the pathology of Borrelia burgdorferi, the bacterium that causes Lyme disease, among human beings and mice. My first thought was "Seriously?! It's too early for this!" My second thought was "well, David, your Twitter sure has evolved from your pre-Lyme days when you used it mostly to promote vapid celebrity interviews." As I began my morning caffeine ritual and read through each of the messages, I gained a new appreciation for some of the real complexities of "in...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind. Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation. You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic.  Research shows that damaged mitochondria can lead to: Schizophrenia and bipolar disorder; Alzheimer’s and Parkinson’s d...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Natural Cures Source Type: news
This week, hundreds of scientists from around the world are descending on Washington D.C. for a three-day summit on a new technique that has spurred a major genetic revolution. Thanks to a gene-editing technique called CRISPR-Cas9, it is now not only possible, but easy, cheap and fast, to change, delete or replace genes in any plant or animal, including people. The range of hypothetical ways CRISPR could change our lives is staggering -- from creating wheat that is invulnerable to mildew to curing the world’s most intractable diseases. Anything that has DNA, which is to say, every living thing on earth, can now be mo...
Source: Science - The Huffington Post - Category: Science Source Type: news
Publication date: Available online 14 July 2015 Source:Joint Bone Spine Author(s): Pascal Sève, Laurent Kodjikian, Léopold Adélaïde, Yvan Jamilloux Rheumatologists may need to establish the etiological diagnosis and handle the therapeutic management of adults with uveitis. To date, no diagnostic strategy for uveitis has been validated by prospective studies. Investigations are selected based on the clinical features and on the anatomic location of the ocular abnormalities. Infections such as syphilis, Lyme disease, tuberculosis, and Whipple's disease may cause uveitis, with concomitant joint...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
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