Genetic-Driven Druggable Target Identification and Validation.

Genetic-Driven Druggable Target Identification and Validation.
Trends Genet. 2018 May 23;:
Authors: Floris M, Olla S, Schlessinger D, Cucca F
Abstract
Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically. Here, we discuss opportunities and challenges, and infer criteria for the optimal use of genetic findings in the drug discovery pipeline.
PMID: 29803319 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - May 23, 2018 Category: Genetics & Stem Cells Authors: Floris M, Olla S, Schlessinger D, Cucca F Tags: Trends Genet Source Type: research