485 endoscopic-ultrasound-guided portal injection chemotherapy (epic) using a novel biodegradable microbead to deliver paclitaxel

Patients with diffuse liver metastases have systemic chemotherapy as their only treatment option. We developed EUS-guided portal injection chemotherapy (EPIC) to increase drug levels in hepatic tissue while sparing systemic exposure as a novel new liver-directed therapy. EPIC uses linear array EUS for transgastric injection of drug-loaded beads directly into the portal vein. Limitations of currently available beads include incompatibility with most chemotherapeutic agents (e.g. paclitaxel) and non-biodegradability.

https://www.giejournal.org/article/S0016-5107(18)30369-9/fulltext?rss=yes

Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: Douglas O. Faigel, Matt Fiala, Douglas Pennington, Taylor Anderson, Steve Kangas Tags: Oral abstract Source Type: research