Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster.

In conclusion, male Drosophila melanogaster exposed to CUMS display a depressive-like phenotype, and, while this poses some limitations as an animal model for depression, it meets some of the criteria required to be a valid model, such as good face and construct validity.
PMID: 29803654 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - May 24, 2018 Category: Neurology Authors: Araujo SM, Poetini MR, Bortolotto VC, de Freitas Couto S, Pinheiro FC, Meichtry LB, de Almeida FP, Santos Musachio EA, de Paula MT, Prigol M Tags: Behav Brain Res Source Type: research