Impact of positive Donor-Specific HLA Antibodies (DSA) crossmatch on graft survival in ABO incompatible liver-kidney transplantation: A case report

We present a patient with positive donor-specific antibodies (DSA) and crossmatch of ABO-incompatible (ABOi) combined liver and kidney transplantation (CLKT). Antibody-mediated rejection did not occur and the graft has survived for over 1 year at the time of writing without infectious complications. A 56-year-old man with positive DSA and positive crossmatch underwent living donor CLKT. The preoperative protocol for ABOi consisted of a single dose of rituximab and total plasma exchange (TPE). The result of Anti-B antibody titer for IgG was 1:32.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research