Optimal Settings for Double Filtration Plasmapheresis with a Targeted Removal Rate of Preexisting Antibody in Antibody-incompatible Kidney Transplant

Elimination of preexisting donor-reactive antibodies is essential for antibody-incompatible kidney transplantation. Double filtration plasmapheresis (DFPP) using albumin (Alb) replacement fluid (Rf) removes immunoglobulin more selectively than plasma exchange; however, fixed-dose treatment can result in insufficient removal of antibody or excess loss of osmotic pressure and subsequent hypotension. The aim of this study was to determine the optimal setting (volume and concentration of Rf) of DFPP to remove donor-reactive antibodies.

Source: Transplantation Proceedings - May 29, 2018 Category: Transplant Surgery Authors: Daiki Iwami, Masayoshi Miura, Yuki Chiba, Minoru Oota, Takenao Matsumoto, Kiyohiko Hotta, Hajime Sasaki, Takayuki Hirose, Hiroshi Harada, Nobuo Shinohara Source Type: research