Quantitative theory of deep brain stimulation of the subthalamic nucleus for the suppression of pathological rhythms in Parkinson ’s disease

by Eli J. M üller, Peter A. Robinson Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is modeled to explore the mechanisms of this effective, but poorly understood, treatment for motor symptoms of drug-refractory Parkinson’s disease and dystonia. First, a neural field model of the corticothalamic-basal ganglia (CTBG) s ystem is developed that reproduces key clinical features of Parkinson’s disease, including its characteristic 4–8 Hz and 13–30 Hz electrophysiological signatures. Deep brain stimulation of the STN is then modeled and shown to suppress the pathological 13–30 Hz (beta) activity for physiologic ally realistic and optimized stimulus parameters. This supports the idea that suppression of abnormally coherent activity in the CTBG system is a major factor in DBS therapy for Parkinson’s disease, by permitting normal dynamics to resume. At high stimulus intensities, nonlinear effects in the tar get population mediate wave-wave interactions between resonant beta activity and the stimulus pulse train, leading to complex spectral structure that shows remarkable similarity to that seen in steady-state evoked potential experiments.
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research