Age-specific ovarian cancer risks among women with a BRCA1 or BRCA2 mutation.

CONCLUSION: Based on a cumulative risk of 0.55% to age 35 for BRCA1 mutation carriers and of 0.56% to age 45 for BRCA2 mutation carriers, we recommend bilateral salpingo-oophorectomy before age 40, but ideally by age 35, for women with a BRCA1 mutation and by age 45 for those with a BRCA2 mutation to maximize prevention and to minimize adverse effects. PMID: 29793803 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29793803?dopt=Abstract

Source: Gynecologic Oncology - May 21, 2018 Category: Cancer & Oncology Authors: Kotsopoulos J, Gronwald J, Karlan B, Rosen B, Huzarski T, Moller P, Lynch HT, Singer CF, Senter L, Neuhausen SL, Tung N, Eisen A, Foulkes WD, Ainsworth P, Sun P, Lubinski J, Narod SA, Hereditary Ovarian Cancer Clinical Study Group Tags: Gynecol Oncol Source Type: research