PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer

In this report, we describe a case of RAAS, and employed immunohistochemical (IHC) staining of PD-L1 and MMP9 as well as periostin, IL-4, and CD163. Interestingly, IHC staining revealed that the RAAS in our case was positive for PD-L1 and negative for MMP9. Moreover, the predominant stromal factor of our case was periostin, suggesting that TAMs in the present case was not immunosuppressive, but an inflammatory subtype. These results might explain, at least in part, the better prognosis of RAAS compared to CAS.Case Rep Oncol 2018;11:330 –335
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research