Sustained impact of rotavirus vaccine on rotavirus hospitalisations in Lusaka, Zambia, 2009-2016.

Sustained impact of rotavirus vaccine on rotavirus hospitalisations in Lusaka, Zambia, 2009-2016. Vaccine. 2018 May 21;: Authors: Mpabalwani EM, Simwaka JC, Mwenda JM, Matapo B, Parashar UD, Tate JE Abstract BACKGROUND: Monovalent rotavirus vaccine (RV1) was introduced in Lusaka in February 2012 and rolled out countrywide in November 2013 in the routine Expanded Programme on Immunisation and administered at 6 and 10 weeks with no catch up dose. Reported here is the monitoring of rotavirus acute gastroenteritis hospitalisations at the University Teaching Hospital, Lusaka, Zambia as part of efforts to document the impact of rotavirus vaccine. METHODS: Children
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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Abstract BACKGROUND: The rotavirus is the most frequent cause of severe diarrhoea in small children. The purpose of this study was to map emergency primary health care consultations due to gastroenteritis in small children before and after the introduction of the rotavirus vaccine on 1 October 2014. MATERIAL AND METHOD: The material consists of data from all electronic reimbursement claims from emergency primary health care doctors in the period 2010-18. Quarterly consultation rates at the emergency primary health care units for children aged 0-4 years with gastroenteritis were calculated. The consultation ra...
Source: Tidsskrift for den Norske Laegeforening - Category: General Medicine Authors: Tags: Tidsskr Nor Laegeforen Source Type: research
AbstractIntroductionRotavirus gastroenteritis is the leading cause of severe diarrhoea among young children
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
In 2016, the Government of India introduced the oral rotavirus vaccine (ROTAVAC, Bharat Biotech, India) in 4 states of India as part of the Universal Immunization Programme, and expanded to 5 more states in 20...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Rotavirus infection is the most common cause of acute gastroenteritis globally in children under 5 years of age and is responsible for approximately 5% of all child deaths yearly. Rotavirus vaccination is cons...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
CONCLUSIONS: Rotavirus vaccines were effective in preventing mild to severe RVGE, irrespective of vaccine type, time since vaccination, or RV genotype. PMID: 30037664 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Publication date: Available online 29 June 2018Source: The LancetAuthor(s): Krisztián Bányai, Mary K Estes, Vito Martella, Umesh D ParasharSummaryEnteric viruses, particularly rotaviruses and noroviruses, are a leading cause of gastroenteritis worldwide. Rotaviruses primarily affect young children, accounting for almost 40% of hospital admissions for diarrhoea and 200 000 deaths worldwide, with the majority of deaths occurring in developing countries. Two vaccines against rotavirus were licensed in 2006 and have been implemented in 95 countries as of April, 2018. Data from eight high-income and middle-incom...
Source: The Lancet - Category: General Medicine Source Type: research
We describe rotavirus prevalence and hospitalisation in Malawi pre and four years post vaccine introduction; provide updated vaccine effectiveness (VE) estimates; and assess rotavirus vaccine indirect effects. METHODS: Children under five years of age presenting to a referral hospital in Blantyre with AGE were recruited. Stool samples were tested for rotavirus using Enzyme Immunoassay. The change in rotavirus prevalence was evaluated using Poisson regression. Time series analysis was used to further investigate trends in prevalence over time. VE against rotavirus diarrhoea of any severity was estimated using logistic ...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusion: The benefit-risk ratio in France is similar to that of other European countries. PMID: 29258644 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
In the West, rotavirus immunisation became routine several years ago, and we are now enjoying the benefits of fewer admissions for infectious diarrhoea. In low-income countries, rotavirus gastroenteritis is not just an inconvenience, but a common and frequently fatal illness. This is particularly true of sub-Saharan Africa. Uptake of mass immunisation has been slow, because of cost and difficulty in getting refrigerated vaccine to remote communities: the ‘cold-chain’ problem. Unlike bacterial enteric pathogens, rotavirus rates are not much reduced by access to clean water and sanitation. Vaccination is the only...
Source: Archives of Disease in Childhood - Category: Pediatrics Authors: Tags: Miscellanea Source Type: research
CONCLUSION:Rotavirus is an important cause of severe diarrhoea in Saudi children. However, the available data on rotavirus strains in circulation are limited and there is an urgent need for up-to-date and comprehensive studies to evaluate rotavirus strains in circulation and identify unusual types that could be incorporated into future vaccines.Ann Saudi Med 2006;26(3):184-191
Source: Annals of Saudi Medicine - Category: General Medicine Tags: ISSUE 3 Source Type: research
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