Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance

Extrathymically generated regulatory (pTreg) cells are induced by bacterial products at mucosal sites. In this issue, Campbell et  al. show that pTreg cell deficiency impedes the establishment of a subset of intestinal bacteria due to heightened immune responses, with significant effects on host metabolites and fitness.

Source: Immunity - May 29, 2018 Category: Allergy & Immunology Authors: Clarissa Campbell, Stanislav Dikiy, Shakti K. Bhattarai, Takatoshi Chinen, Fanny Matheis, Marco Calafiore, Beatrice Hoyos, Alan Hanash, Daniel Mucida, Vanni Bucci, Alexander Y. Rudensky Tags: Article Source Type: research