Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response

The link between human IRF8 mutations and immunodeficiency is poorly understood. Adams et  al. demonstrate that IRF8 is required for NK-cell-mediated antiviral immunity by promoting proliferation of virus-specific NK cells.

Source: Immunity - May 29, 2018 Category: Allergy & Immunology Authors: Nicholas M. Adams, Colleen M. Lau, Xiying Fan, Moritz Rapp, Clair D. Geary, Orr-El Weizman, Carlos Diaz-Salazar, Joseph C. Sun Tags: Article Source Type: research