Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells

Gentek et  al. demonstrate that Cdh5-CreERT2 can be used to selectively fate map yolk sac and definitive hematopoiesis. Temporally defined Cdh5-CreERT2 lineage tracing reveals that mast cells are yolk sac derived in the embryo but replaced by definitive hematopoiesis in the adult, a feature they share with m acrophages.

Source: Immunity - May 29, 2018 Category: Allergy & Immunology Authors: Rebecca Gentek, Cl ément Ghigo, Guillaume Hoeffel, Maxime Jacques Bulle, Rasha Msallam, Gregory Gautier, Pierre Launay, Jinmiao Chen, Florent Ginhoux, Marc Bajénoff Tags: Article Source Type: research