Serum Fas Ligand, Serum Myostatin and Urine TGF- β1 Are Elevated in Autosomal Dominant Polycystic Kidney Disease Patients with Impaired and Preserved Renal Function

Conclusions: ADPKD patients with moderately preserved renal function have higher levels of FasL, myostatin and urine TGF- β1 than controls. These results indicate that an interplay between endothelial dysfunction and renal ischemia with mechanisms linked to apoptosis and fibrosis may be present even in early stages of ADPKD.Kidney Blood Press Res 2018;43:744 –754
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research