A pyrrocidine derivative produced by fungus Neonectria ramulariae In-2 isolated from a Beetle Holotrichia picea

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Yoshihito Shiono, Mariko Furukawa, Takuya Koseki, Eunsang Kwon, Andreas Hendracipta Kurniawan, Satoru Sato, Desi Harneti, Rani Maharani, Unang Supratman, Shota Uesugi, Ken-ichi Kimura A new pyrrocidine A derivative, 19-epi-pyrrocidine A (1) was isolated from the insect–derived fungus Neonectria ramulariae In-2, together with known pyrrocidine A (2). The structure of 1 was determined by extensive 1D- and 2D-NMR, and MS spectral analyses. The absolute configuration of 2 was confirmed for the first time by X-ray crystallography. Compound 1 exhibited cytotoxicity against human acute promyelocytic leukemia HL60 cells (IC50 2.05 μM). In addition, semi-synthetic compounds 19-O-methyl-pyrrocidine A (3), 19-O-acetyl-pyrrocidine A (4), and 1,2-4,5-17,18-triepoxy-pyrrocidine A (5) were found to possess significant cytotoxicity, with IC50 values of 0.66 μM, 0.19 μM, and 2.00 μM, respectively. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
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Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
PMID: 31721689 [PubMed - in process]
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: European Journal of Radiology - Category: Radiology Source Type: research
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Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Source Type: research
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