Georgia Regents University Launches Immunotherapy Clinical Trial

The Georgia Regents University Cancer Center, a national leader in immunotherapy research, has opened its first clinical trial for mesothelioma patients. The Phase 2 trial is open to patients with unresectable peritoneal or pleural mesothelioma, providing a promising new treatment option for this rare and aggressive cancer. Immunotherapy involves triggering the body's own immune system to identify and destroy the cancer cells without harming the healthy ones. This multicenter trial will study the drug tremelimumab, which has shown an ability to stimulate the immune system and attack tumors. It already has shown potential in treating other cancers. The Georgia Regents University (GRU) is the only one in the Georgia-South Carolina region. Mesothelioma is an asbestos-related cancer that can affect the lining surrounding the lungs (pleural), heart (pericardial) or abdominal cavity (peritoneal). Doctors diagnose an estimated 3,000 cases annually in the U.S. Average life expectancy ranges from nine to 24 months, depending on several factors. "There just aren't a lot of options for mesothelioma patients. Those in our state have had to travel quite a distance, north or south, for a trial like this," GRU Cancer Center Director Samir Khleif, M.D., told Asbestos.com. "We needed to provide something for those patients in our area." GRU Cancer Center Is a Leader in Immunotherapy The GRU Cancer Center, located in Augusta, Georgia, puts a heavy emphasis on immunother...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Research & Clinical Trials Source Type: news

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Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Cody T. Mowery, Jaime M. Reyes, Lucia Cabal-Hierro, Kelly J. Higby, Kristen L. Karlin, Jarey H. Wang, Robert J. Kimmerling, Paloma Cejas, Klothilda Lim, Hubo Li, Takashi Furusawa, Henry W. Long, David Pellman, Bjoern Chapuy, Michael Bustin, Scott R. Manalis, Thomas F. Westbrook, Charles Y. Lin, Andrew A. LaneSummaryDown syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes, we performed paired exogenous spike-in normalized RNA and ...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Daniel S.J. Miller, Robert D. Bloxham, Ming Jiang, Ilaria Gori, Rebecca E. Saunders, Debipriya Das, Probir Chakravarty, Michael Howell, Caroline S. HillSummarySignal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The trafficking of cell surface receptors is emerging as a key step for regulating appropriate cellular responses, with perturbations in this process contributing to human diseases, including cancer. For receptors recognizing ligands of...
Source: Cell Reports - Category: Cytology Source Type: research
Radiation seems to specifically injure the brain region involved in learning and forming new memories.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Publication date: Available online 13 November 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. HoffmannAbstractSchistosomiasis endangers the lives of greater than 200 million people every year and is predominantly controlled by a single class chemotherapy, praziquantel (PZQ). Development of PZQ replacement (to combat the threat of PZQ insensitivity/resistance arising) or combinatorial (to facilitate the killing of PZQ-insensitive juvenile schistosomes) chemotherapies would help sustain this control strategy i...
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research
A California jury on Wednesday cleared Johnson&Johnson of liability in a case involving a woman who alleged that the company's talc-based products, including its baby powder, contain asbestos and caused her cancer, the company said.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Intricate pathway through which cancer cells likely spread to bone now opens the door to its pharmaceutical blockade and potentially mitigate against metastatic disease progression.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
The objective of this study was to characterize Somali Bantu and Karen experiences with cancer and cancer screenings prior to and subsequent to resettlement in Buffalo, NY in order to inform engagement by health providers. METHODS: The study was grounded in a community-based participatory research approach, with data collection and analysis guided by the Health Belief Model and life course framework. Interviews were transcribed, independently coded by two researchers, and analyzed using an immersion-crystallization approach. We conducted 15 semi-structured interviews and six interview-focus group hybrids with Somali Ba...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Publication date: 15 January 2019Source: Journal of Molecular Liquids, Volume 274Author(s): Yue Jiang, Xu Hu, Jing Zhang, Guoxia Jin, Yuxia LuanAbstractA prodrug-participating catanionic system was developed for effective delivery of the chemotherapeutic agent chlorambucil (CLB). The catanionic aggregates were easily formed by mixing as-synthesized cationic CLB prodrug, N-(2-amino-ethyl)-4-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-butyramide (CLBM) and conventional anionic surfactant sodium bis (2-ethylhexyl) sulfosuccinate (AOT). The aggregation properties, morphology and release behaviour of the CLBM-AOT aggregates were in...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
This study focused on the possible role of SEC24 proteins in ATB0,+ trafficking. Rat ATB0,+ was expressed in HEK293 cells, its localization and trafficking were examined by Western blot, deglycosylation, immunofluorescence (co-localization with ER and trans-Golgi markers) and biotinylation. The expression of ATB0,+ at the plasma membrane was decreased by dominant negative mutants of SAR1, a GTPase, whose activity triggers the formation of the COPII complex. ATB0,+ co-precipitated with SEC24C (but not with the remaining isoforms A, B and D). This interaction was confirmed by immunocytochemistry and the proximity ligation as...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
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