Georgia Regents University Launches Immunotherapy Clinical Trial
The Georgia Regents University Cancer Center, a national leader in immunotherapy research, has opened its first clinical trial for mesothelioma patients. The Phase 2 trial is open to patients with unresectable peritoneal or pleural mesothelioma, providing a promising new treatment option for this rare and aggressive cancer. Immunotherapy involves triggering the body's own immune system to identify and destroy the cancer cells without harming the healthy ones. This multicenter trial will study the drug tremelimumab, which has shown an ability to stimulate the immune system and attack tumors. It already has shown potential in treating other cancers. The Georgia Regents University (GRU) is the only one in the Georgia-South Carolina region. Mesothelioma is an asbestos-related cancer that can affect the lining surrounding the lungs (pleural), heart (pericardial) or abdominal cavity (peritoneal). Doctors diagnose an estimated 3,000 cases annually in the U.S. Average life expectancy ranges from nine to 24 months, depending on several factors. "There just aren't a lot of options for mesothelioma patients. Those in our state have had to travel quite a distance, north or south, for a trial like this," GRU Cancer Center Director Samir Khleif, M.D., told Asbestos.com. "We needed to provide something for those patients in our area." GRU Cancer Center Is a Leader in Immunotherapy The GRU Cancer Center, located in Augusta, Georgia, puts a heavy emphasis on immunother...
Authors: Krajewski W, Halska U, Poletajew S, Piszczek R, Bieżyński B, Matyjasek M, Tukiendorf A, Menzel F, Mazur M, Rymaszewska J, Zdrojowy R Abstract The standard of care in non-muscle invasive bladder cancer consists of transurethral tumor resection. The aim of this study was to evaluate the influence of transurethral resection of bladder tumor (TURB) on the patients' self-reported depression, anxiety, sexual satisfaction, and erectile dysfunction. Psychological condition of 252 male patients who underwent TURB was prospectively evaluated. The Hospital Anxiety and Depression Scale (HADS), simplified Internation...
CONCLUSION: In conclusion, hASCs exhibited some particular characteristics of aged stem cells when the number of subculture cells increased. However, up to passage 10, ASCs also retained almost all of the characteristics of MSCs. PMID: 30242785 [PubMed - as supplied by publisher]
Authors: Gee AP Abstract Cellular therapies have moved to the forefront based upon promising results from clinical trials using both chimeric antigen receptor T lymphocytes to treat leukemia and other cell types to restore structure and function to tissues that have been damaged by disease or physical injury. The pace at which these treatments have evolved has posed a regulatory challenge to agencies, such as the Food and Drug Administration (FDA). This chapter describes how a specific regulatory strategy was developed and how it has evolved in response to the demand for these new therapies. PMID: 30238372 [PubMed - in process]
Conclusions: We found that several conserved tumor stromal genes might regulate breast cancer invasion through ECM remodeling. The clinical outcome analyses of COL1A1 and FN1 suggest these two genes are promising targets for future studies. PMID: 30237810 [PubMed - in process]
We report 45 common human miRNAs deregulated in both pulmonary tuberculosis and lung cancer. We show that sRNA_1096 and sRNA_1414 from M. tuberculosis have sequence homology with human mir-21. Hence, the potential role of these three small non-coding RNAs in rifampicin resistance in pulmonary tuberculosis is implied. Further, the linking of sRNA_1096 and sRNA_1414 from M. tuberculosis with the host lung tumorigenesis is inferred. Nonetheless, further analysis and validation is required to associate these three non-coding RNAs with Mycobacterium associated increased risk of lung cancer. PMID: 30237679 [PubMed]
Conclusion: High adherence was associated with a healthier lifestyle, both concerning diet and other factors. Energy adjustment of potential confounding foods removed associations between high adherence and less healthy foods. The Nordic foods accounted for a larger fraction of the diet among high adherers, at the expense of other healthy foods. Careful adjustment for confounders is warranted when assessing associations between the index and health outcomes. PMID: 30237757 [PubMed]
Contributors : Hiromu Suzuki ; Koyo NishiyamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe identified DLEU1 as a long noncoding RNA (lncRNA) frequently overexpressed in oral squamous cell carcinoma (OSCC). Knockdown of DLEU1 suppressed proliferation, migration and invasion and induced cell cycle arrest and apoptosis in OSCC cells. To further clarify the molecular function of DLEU1, we carried out gene expression microarray analysis in OSCC cell lines with DLEU1 knockdown. We found that genes associated with “matrix metalloproteinases”, “apoptosis”, “cell cycle” and...
CONCLUSION: Of all cancers expected in 2018 in Germany, at least 5% are attributable to potentially avoidable infections and environmental factors. Further research should be directed towards more comprehensive identification and quantification of environmental risks as a basis for targeted cancer prevention. PMID: 30236218 [PubMed - in process]
CONCLUSION: A considerable proportion of cancer cases are attributable to excess weight, physical inactivity, and unhealthy dietary habits. Major prevention efforts are needed to reduce the cancer incidence attributable to these avoidable factors. PMID: 30236216 [PubMed - in process]
CONCLUSIONS: A considerable proportion of cancer cases are attributable to smoking and high alcohol consumption. More rigorous prevention efforts are required to achieve significant reductions in the prevalence of these risk factors and the attributable cancer burden. PMID: 30236215 [PubMed - in process]
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