Arrhythmia genetics: Not dark and lite, but 50 shades of gray

The congenital long QT syndromes (cLQTS) were first described more than half a century ago. We now recognize multiple genetic and clinical subtypes, and the exploration of the disease has informed not only family screening but also our fundamental understanding of the electrophysiology of repolarization. Along with this new knowledge has come a new set of challenges centered around interpretation of the relationship between the presence of a variant in a known cLQTS disease gene and its relationship to phenotype.
Source: Heart Rhythm - Category: Cardiology Authors: Tags: Editorial Commentary Source Type: research