Three new 2-(2-phenylethyl)chromone derivatives from artificial holing agarwood of Aquilaria sinensis

Publication date: August 2018 Source:Phytochemistry Letters, Volume 26 Author(s): Tong-Dong Kuang, Hui-Qin Chen, Fan-Dong Kong, Cai-Hong Cai, Li Yang, Wen-Li Mei, Hao-Fu Dai Three new 2-(2-phenylethyl)chromone derivatives (1–3) were obtained from the artificial holing agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced by detailed spectroscopic analysis and the absolute configurations were determined by ECD calculations. Compounds 1–3 displayed acetylcholinesterase (AChE) inhibitory activity with the inhibition ratios in the range of 30%–45% at a concentration of 50 μg/ml. Graphical abstract

Source: Phytochemistry Letters - May 26, 2018 Category: Chemistry Source Type: research