SERPINA1 Hepatocyte-Specific Promoter Polymorphism Associate with Chronic Obstructive Pulmonary Disease in a Study of Kashmiri Ancestry Individuals

ConclusionThe polymorphism associated with hepatocyte-specific promoter region ( − 10T/C) is likely to be associated with the pathogenesis of COPD. It is quite possible that the change of the base in the hepatocyte-specific promoter of theSERPINA1 gene can modulate its strength, thereby driving the reduced expression of α1AT.
Source: Lung - Category: Respiratory Medicine Source Type: research