Anti-M üllerian hormone levels and incidence of early natural menopause in a prospective study

AbstractSTUDY QUESTIONAre anti-M üllerian hormone (AMH) levels assessed in women aged 32–44 associated with risk of incident early natural menopause?SUMMARY ANSWERWe observed strong, significant associations between lower AMH levels and higher risk of early menopause.WHAT IS KNOWN ALREADYThe ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention. Though AMH is an established marker of menopause timing in older reproductive-aged women, whether AMH is associated with risk of early menopause has not been evaluated.STUDY DESIGN, SIZE, DURATIONWe assessed these relations in a nested case –control study within the prospective Nurses’ Health Study II cohort. Premenopausal blood samples were collected in 1996–1999. Participants were followed until 2011 for early natural menopause, with follow-up rates>94%.PARTICIPANTS/MATERIALS, SETTING, METHODSEarly menopause cases (n = 327) were women reporting natural menopause between blood collection and age 45. Controls (n = 491) experienced menopause after age 45 and included 327 cases matched to controls on the basis of age at blood draw ( ±4 months) and other factors. AMH levels up to 12 years before early menopause were assayed in 2016.MAIN RESULTS AND THE ROLE OF CHANCEIn multivariable conditional logistic regression models adjusting for matching factors, body mass index, smoking, parity, oral contra...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research