Preferential Inputs from Cholecystokinin-Positive Neurons to the Somatic Compartment of Parvalbumin-Expressing Neurons in the Mouse Primary Somatosensory Cortex.

Preferential Inputs from Cholecystokinin-Positive Neurons to the Somatic Compartment of Parvalbumin-Expressing Neurons in the Mouse Primary Somatosensory Cortex. Brain Res. 2018 May 21;: Authors: Hioki H, Sohn J, Nakamura H, Okamoto S, Hwang J, Ishida Y, Takahashi M, Kameda H Abstract Parvalbumin-positive (PV+) neurons in the cerebral cortex, mostly corresponding to fast-spiking basket cells, have been implicated in higher-order brain functions and psychiatric disorders. We previously demonstrated that the somatic compartment of PV+ neurons received inhibitory inputs mainly from vasoactive intestinal polypeptide (VIP)+ neurons, whereas inhibitory inputs to the dendritic compartment were derived mostly from PV+ and somatostatin (SOM)+ neurons. However, a substantial number of the axosomatic inputs have remained unidentified. Here we show preferential innervation of the somatic compartment of PV+ neurons by cholecystokinin (CCK)+ neurons in the mouse primary somatosensory cortex. CCK+ neurons, a minor population of GABAergic neurons (3.2%), displayed no colocalization with PV or SOM immunoreactivity but partial overlap with VIP immunoreactivity (27.7%). Confocal laser scanning microscopy observation of CCK+ synaptic inputs to PV+ neurons revealed that CCK+ neurons preferred the somatic compartment to the dendritic compartment of PV+ neurons and provided approximately 33% of the axosomatic inhibitory inputs to PV+ neurons. Additionally,...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research