Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy

Chronic pressure overload and a variety of mediators induce concentric cardiac hypertrophy. When prolonged, cardiac hypertrophy culminates in decreased myocardial function and heart failure. Activation of the extracellular signal-regulated kinase (ERK) is consistently observed in animal models of hypertrophy and in human patients, but its role in the process is controversial.

Source: International Journal of Cardiology - May 24, 2018 Category: Cardiology Authors: Michael Mutlak, Michal Schlezinger-Lau, Tali Haas, Rona Shofti, Nimer Ballan, Yair E. Lewis, Mor Zuler, Yaniv Zohar, Lilac H. Caspi, Izhak Kehat Source Type: research