Ichthyosis molecular fingerprinting shows profound Th17-skewing and a unique barrier genomic signature

DNA alterations are progressively understood in ichthyoses. However, comprehensive phenotyping could direct much-needed targeted therapeutics. Our molecular fingerprinting highlights IL-17/IL-36 responses and unique associated barrier alterations in ichthyoses, advocating for IL-17/IL-36-directed antagonism for these patients.

Source: Journal of Allergy and Clinical Immunology - May 24, 2018 Category: Allergy & Immunology Authors: Kunal Malik, Helen He, Thy Nhat Huynh, Gary Tran, Kelly Mueller, Kristina Doytcheva, Yael Renert-Yuval, Tali Czarnowicki, Shai Magidi, Margaret Chu, Yeriel D. Estrada, Huei-Chi Wen, Xiangyu Peng, Hui Xu, Xiuzhong Zheng, James G. Krueger, Amy S. Paller, Em Source Type: research