Hypothesizing the potential complications of using DNA mismatch repair gene inhibition in cancer therapy

Recent studies have shown that inactivation of (DNA mismatch repair gene) MMR could be exploited as a potential therapeutic tool in cancer therapy [1 –3]. MMR inactivation has shown to increase the mutational load of the cancer cells which in turn causes a sustained antigenic response against the neoantigens (additional mutations) leading to tumor inhibition. Although in-vitro and animal based in-vivo studies have shown the effectiveness of MMR inhibition (flow chart 1) [3] on halting the tumor progression, there are potential complications which could arise due to MMR inactivation.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research