Dihydrochalcone molecules destabilize Alzheimer's amyloid-[small beta] protofibrils through binding to the protofibril cavity

Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP01631C, PaperYibo Jin, Yunxiang Sun, Jiangtao Lei, Guanghong Wei Alzheimer's disease (AD) is associated with the aggregation of amyloid-[small beta] (A[small beta]) peptides into toxic fibrillar aggregates. Finding effective inhibitors of A[small beta] aggregation is a crucial step for the development of... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Phys. Chem. Chem. Phys. latest articles - May 24, 2018 Category: Chemistry Authors: Yibo Jin Source Type: research