Graft function assessment in mouse models of single- and dual- kidney transplantation.

In conclusion, we have successfully generated a mouse DKT model. The hemodynamic responses of DKT better mimic physiological situations with less kidney injury and better recovery than SKT because of reduced confounding factors such as single nephron hyperfiltration. We anticipate DKT in mice will provide an additional tool for evaluation of renal significance in physiology and disease.
PMID: 29790388 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - May 23, 2018 Category: Urology & Nephrology Authors: Wang L, Wang X, Jiang S, Wei J, Buggs J, Fu L, Zhang J, Liu R Tags: Am J Physiol Renal Physiol Source Type: research