NEAT1 upregulates TGF ‐β1 to induce hepatocellular carcinoma progression by sponging hsa‐mir‐139‐5p

Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research

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Authors: Imai M, Ishikawa T, Okoshi M, Tomiyoshi K, Kojima Y, Horigome R, Nozawa Y, Sano T, Iwanaga A, Honma T, Nemoto T, Takeda K, Nishikura K, Ishihara N, Yoshida T Abstract A 62-year-old man initially underwent transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma (HCC). One year after the initial treatment, he developed anemia. Upper gastrointestinal endoscopy revealed irregularly elevated tumors in the lower anterior gastric body, which were diagnosed to be metastasis from HCC. Left gastric artery coil embolization was performed to prevent sustained bleeding, and his anemia par...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
In this study, in seven distinct multi-generation families we found the causative gene for a rare Mendelian form of NAFLD. In a large Italian family with nine affected members with NAFLD and/or dyslipidemia, whole exome sequencing identified a heterozygous stop codon mutation in ABHD5.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
Publication date: Available online 17 April 2019Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Jia-Xi Mao, Fei Teng, Cong Liu, Hang Yuan, Jia-Yong Dong, Hong Fu, Guo-Shan Ding, Wen-Yuan Guo
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
AbstractHemodialysis patients are at increased risk for development of blood-borne viral infections. Human immunodeficiency virus (HIV), a once fatal infection, has become treatable, but continues to be associated with increased mortality. Hepatitis B and C viral infections can lead to acute and chronic hepatitis, cirrhosis, or hepatocellular carcinoma. Young children and immunocompromised patients are more likely to develop chronic disease leading to increased morbidity and mortality, as compared to the healthy population. The hemodialysis population is at increased risk of blood-borne viral infections as compared to the ...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Type 2 diabetes is a risk factor for development of cirrhosis and hepatocellular carcinoma. However, risk factor that identify persons with the highest risk for these outcomes are missing from unselected, population-based cohorts.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
ConclusionsWe developed a method for quantitating tumor blush using routine angiographic images. The VEVs calculated using these images may allow for the prediction of tumor response to therapy. This pilot study suggests that there is a correlation between tumor blush intensity and tumor response.
Source: Abdominal Imaging - Category: Radiology Source Type: research
ei Chen A new electrochemical immunosensor for cancer cell detection based on a specific interaction between the metastasis-related antigen of epithelial cell adhesion molecule (EpCAM) on the cell membrane and its monoclonal antibody (Anti-EpCAM) immobilized on a gold electrode has been developed. The amino-terminated polyamidoamine dendrimer (G6 PAMAM) was first covalently attached to the 3-mercaptopropionic acid (MPA)-functionalized gold electrode to obtain a thin film, and then completely carboxylated by succinic anhydride (SA). Next, the Anti-EpCAM was covalently bound with the G6 PAMAM to obtain a stable recogniti...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Song et  al1 recently published a report in Clinical Gastroenterology and Hepatology on their findings from a large population-based cohort study. Their study evaluated the relationship between hepatocellular carcinoma (HCC) incidence and risk factors among a group of 37,555 subjects in China with differen t hepatitis B surface antigens (HBsAg seroclearance, HBsAg persistent carriers, and HBsAg negative). They concluded that metabolic disease (obesity or fatty disease) may play a role in liver tumorigenesis in patients with HBsAg seroclearance.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Authors: Li Y, Xu A, Jia S, Huang J Abstract Hepatocellular carcinoma (HCC) is more frequently observed and aggressive in men compared with women. Increasing evidence demonstrates that the sex disparity appears to be mediated by the stimulatory effects of androgens and the protective effects of estrogen in the development and progression of HCC. In the past few decades, studies on the sex difference of HCC mainly focused on the effect of sex hormones on the transactivation of hepatitis B virus X protein and the release of inflammatory cytokines, and these studies have further intensified in recent years. Sex hormon...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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