NEAT1 upregulates TGF ‐β1 to induce hepatocellular carcinoma progression by sponging hsa‐mir‐139‐5p

Journal of Cellular Physiology, EarlyView.
Source: Journal of Cellular Physiology - Category: Cytology Authors: Source Type: research

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Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Heba K.A. Elhakim, Shereen M. Azab, Amany M. FekryAbstractA novel sensitive electrochemical sensor for microRNAlet-7a detection in normal serum samples, hepatocellular carcinoma patients and human liver cancer cells, has been excellently synthesized. The sensor constructed of carbon paste (CP) amended with silver nanoparticles (AgNPs) and extracted propolis (bee glue). The AgNPs/P modified carbon paste electrode (APCPE) displayed a high electrocatalytic activity in a Britton Robinson (BR) buffer (pH = 7.4). The techniques...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Ghassan Abou-Alfa, MD, MBA, explains the shortcomings of the RECIST study in measuring efficacy in hepatocellular carcinoma (HCC) patients at ASCO 2018. Author: obr Added: 07/20/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
This study was conducted on a total number of 59patients. These were subdivided into 25patients of hepatocellular carcinoma and 34 patients of chronic liver diseases (CLDs) with cirrhosis. All studied 59patients were associated with HCV infection. All patients were examined immunohistochemically to demonstrate the expression of MyeloperoxidaseResultsConcerning the expression of Myeloperoxidase in HCC and cirrhoticpatients; the study revealed that more MPO expression was found in HCC cases when compared with cirrhoticpatients (P –value
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: September 2018Source: European Journal of Radiology, Volume 106Author(s): Davide Ippolito, Giulia Querques, Stefano Okolicsanyi, Cammillo Talei Franzesi, Anna Pecorelli, Sophie Lombardi, Eleonora Orsini, Mario Strazzabosco, Sandro SironiAbstractPurposeTo investigate whether perfusion-CT (p-CT) imaging could depict the inhibition of tumor neoangiogenesis induced by Sorafenib in advanced hepatocellular carcinoma (HCC), and whether it could be useful in predicting survival during treatment.Materials and methodsNinety-eight p-CT examinations were performed among 29 cirrhotic patients, with advanced HCC, befor...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Authors: Kotha S, Neong S, Patel K Abstract INTRODUCTION: Chronic liver disease due to viral hepatitis continues to be a major global health concern. Timely diagnosis and treatment will prevent cirrhosis, risk of hepatocellular carcinoma (HCC), and requirement for liver transplantation. Numerous serum biomarkers are available for viral hepatitis that are helpful in diagnosis, measuring severity, progression of disease, evaluating the best therapeutic options, and monitoring antiviral treatment response. Determining the clinical use of available diagnostic tests can be challenging for the health care provider. Areas...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
omas Tu Infection with the Hepatitis B Virus (HBV) is one of the strongest risk-factors for liver cancer (hepatocellular carcinoma, HCC). One of the reported drivers of HCC is the integration of HBV DNA into the host cell genome, which may induce pro-carcinogenic pathways. These reported pathways include: induction of chromosomal instability; generation of insertional mutagenesis in key cancer-associated genes; transcription of downstream cancer-associated cellular genes; and/or formation of a persistent source of viral protein expression (particularly HBV surface and X proteins). The contribution of each of these spec...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
The optimal treatment for oesophageal cancer is a matter of debate. The aim of this study was to describe patterns of care and survival in a well-defined population for squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the oesophagus.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Oncology Source Type: research
ConclusionTo sum up, this meta-analysis suggests that the rs361525 and rs1800629 are not associated with HCC development while geographical distance effect on rs361525 genetic inheritance but not effect on rs1800629. However, it is necessary to conduct further studies with larger sample. Moreover, gene-gene and gene-environment interactions should also be considered.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
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Source: Expert Opinion on Biological Therapy - Category: Drugs & Pharmacology Authors: Source Type: research
Publication date: August 2018Source: The American Journal of Surgery, Volume 216, Issue 2Author(s): Andrea Mancuso, Alberto Maringhini
Source: The American Journal of Surgery - Category: Surgery Source Type: research
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