The P2X4 purinergic receptor regulates hepatic myofibroblast activation during liver fibrogenesis

Beside huge regenerative properties, the liver classically undergoes fibrogenesis in association with liver repair during chronic injury, impairing hepatic functions with high morbidity and mortality [1]. As well as in other organs, in the liver, the main cellular contributor to excessive extracellular matrix (ECM) deposition is the myofibroblast, derived from hepatic stellate cells and/or portal fibroblasts [2] after acute or during chronic liver injury. Hepatic myofibroblasts (hMF) are characterized by alpha smooth muscle actin ( α-SMA) expression, contractile properties, and by overexpressed ECM components and regulators.

Source: Journal of Hepatology - May 23, 2018 Category: Gastroenterology Authors: Camille Le Guilcher, Isabelle Garcin, Olivier Dellis, Florent Cauchois, Ali Tebbi, Isabelle Doignon, Catherine Guettier, Boris Julien, Thierry Tordjmann Source Type: research