Manipulating macrophage polarization and function using classical HDAC inhibitors: implications for autoimmunity and inflammation

Macrophages are important player in defense against invading pathogens and their dysfunction is linked to most of inflammatory and autoimmune diseases. Inflammation is a normal and physiological response of the immune system against harmful stimuli such as infection and injury. However, when allowed to continue unchecked, under certain conditions it turns into autoimmune or inflammatory diseases, neurodegeneration, and carcinogenesis. Currently, several safe and effective anti-inflammatory drugs are available with many more drugs in the development pipeline, among which are histone deacetylase inhibitors.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research