Differential effects of deep-brain stimulation of the internal capsule and the striatum on excessive grooming in Sapap3 mutant mice.

Deep-brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is thought to underlie its beneficial effects in OCD.

Source: Biological Psychiatry - May 23, 2018 Category: Psychiatry Authors: Cindy M. Pinhal, Bastijn J.G. van den Boom, Fabiana Santana-Kragelund, Lizz Fellinger, Pol Bech, Ralph Hamelink, Guoping Feng, Ingo Willuhn, Matthijs G.P. Feenstra, Damiaan Denys Tags: Archival Report Source Type: research