Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis

Condition:   Desmoid TumorInterventions:   Drug: sorafenib tosylate;   Other: placebo;   Other: laboratory biomarker analysis;   Other: quality-of-life assessmentSponsor:   National Cancer Institute (NCI)Recruiting - verified September 2014
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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We report an unusual head tumour with extremely rare extensiveness and aggressivness. The patient was 18-year-old female with three-day-lasting headache and repetitive oral bleeding. Computed tomography revealed a large, well-circumscribed, expansile mass occupying ethmoid cells, nasal cavities and ventral part of the sphenoid sinus, with extention into the anterior cranial fossa. Pterional craniotomy was carried out. On one-year follow-up recurrence of the lesion was identified and the second surgery was performed. The lesion is under supervision now, due to incomplete removal.PMID:35048642 | DOI:10.5114/pjp.2021.111779
Source: Polish Journal of Pathology - Category: Pathology Authors: Source Type: research
Pol J Pathol. 2021;72(3):252-260. doi: 10.5114/pjp.2021.111776.ABSTRACTDesmoid-type fibromatosis is locally aggressive tumor rare in general population, although commonly present in patients with familial adenomatous polyposis, significantly contributing to the morbidity and mortality of patients. To optimize and individualize the management of patients it is necessary to better understand the biology of these tumors. Immunohistochemical analysis of β-catenin, VEGF, hormone receptors ERβ, ERα and PR, COX-2, APC protein, EGFR, c-kit (CD117), bcl-2 and HER2 expression, potential therapeutic targets, was carri...
Source: Polish Journal of Pathology - Category: Pathology Authors: Source Type: research
We present a biopsy-proven case that arose as a result of heavy gym-related activities. In particular, a heavy barbell was rested on his vertebral prominence at the level of C7/T1 during leg squatting. Repetitive trauma as a cause for extra-nuchal-type fibromas has been sparsely reported, but we suggest that sustained high pressure is an additional required feature. Although this lesion was in the posterior neck, it was contained entirely within the subcutaneous tissues without involvement of the nuchal ligament. Hence, it was considered an extra-nuchal fibroma. A description of key ultrasound and MRI imaging characteristi...
Source: Skeletal Radiology - Category: Radiology Source Type: research
Hautarzt. 2022 Jan 14. doi: 10.1007/s00105-021-04935-w. Online ahead of print.ABSTRACTThere are many different types of skin neoplasms in children and most are benign. Dermatologists should be able to differentiate between the various types of benign skin neoplasms and be able to recommend optimal treatment to concerned patients. Surgical removal of benign skin neoplasms is often the only treatment option. The aim of this paper is to provide a general overview of epidermal lesions (e.g., inflammatory linear verrucous epidermal nevus [ILVEN], nevus sebaceous), tumors of the epidermal appendages (e.g. pilomatrixoma), cutaneo...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Authors: Source Type: research
Int J Clin Exp Pathol. 2021 Dec 15;14(12):1167-1171. eCollection 2021.ABSTRACTCardiac fibroma is a rare primary benign cardiac tumor, especially in adults. It often occurs in the interventricular septum and free wall of the left ventricle and is solitary and space-occupying with clear boundaries. Here we report a 27-year-old male with a cardiac fibroma in the right ventricle, with extensive infiltrative growth. He was admitted to hospital with the complaint of exertional chest tightness, shortness of breath, hemoptysis, and edema of lower extremities. Ultrasound showed a large right ventricular mass blocking the outflow tr...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Source Type: research
Hautarzt. 2022 Jan 14. doi: 10.1007/s00105-021-04935-w. Online ahead of print.ABSTRACTThere are many different types of skin neoplasms in children and most are benign. Dermatologists should be able to differentiate between the various types of benign skin neoplasms and be able to recommend optimal treatment to concerned patients. Surgical removal of benign skin neoplasms is often the only treatment option. The aim of this paper is to provide a general overview of epidermal lesions (e.g., inflammatory linear verrucous epidermal nevus [ILVEN], nevus sebaceous), tumors of the epidermal appendages (e.g. pilomatrixoma), cutaneo...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Authors: Source Type: research
Int J Clin Exp Pathol. 2021 Dec 15;14(12):1167-1171. eCollection 2021.ABSTRACTCardiac fibroma is a rare primary benign cardiac tumor, especially in adults. It often occurs in the interventricular septum and free wall of the left ventricle and is solitary and space-occupying with clear boundaries. Here we report a 27-year-old male with a cardiac fibroma in the right ventricle, with extensive infiltrative growth. He was admitted to hospital with the complaint of exertional chest tightness, shortness of breath, hemoptysis, and edema of lower extremities. Ultrasound showed a large right ventricular mass blocking the outflow tr...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Source Type: research
Desmoid tumor is a rare disease, which is histologically characterized by local invasion, monoclonality, and fibroblast proliferation; and clinically characterized by a variable and often unpredictable course. The treatment of desmoid tumor is mainly surgical resection, but the recurrence rate is high. In recent years, a variety of treatment methods, including endocrine therapy, surgery, radiotherapy, chemotherapy, non-steroidal anti-inflammatory drugs, targeted drugs, interferon and more, have been used and achieved certain curative effects. In addition, in view of the inertia characteristics of desmoid tumor, observation...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Asian J Surg. 2022 Jan 7:S1015-9584(21)00773-9. doi: 10.1016/j.asjsur.2021.12.012. Online ahead of print.NO ABSTRACTPMID:35012853 | DOI:10.1016/j.asjsur.2021.12.012
Source: Asian Journal of Surgery - Category: Surgery Authors: Source Type: research
Acta Med Port. 2022 Jan 10. doi: 10.20344/amp.16083. Online ahead of print.NO ABSTRACTPMID:35006067 | DOI:10.20344/amp.16083
Source: Acta Medica Portuguesa - Category: General Medicine Authors: Source Type: research
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