PET imaging of the influence of physiological and pathological α-synuclein on dopaminergic and serotonergic neurotransmission in mouse models.

CONCLUSIONS: This PET study highlights an effect of α-syn modulation on the expression of the D2 receptor, whereas aggregated α-syn leads to overexpression of 5-HT1A receptor, as a pathophysiological signature.
PMID: 29781098 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - May 20, 2018 Category: Neuroscience Authors: Levigoureux E, Bouillot C, Baron T, Zimmer L, Lancelot S Tags: CNS Neurosci Ther Source Type: research