Neuregulin-1 attenuates stress-induced vascular senescence

ConclusionsThis study is the first to explore the role of NRG-1 in vascular senescence. Our data demonstrate that NRG-1 markedly inhibits stress-induced premature senescence in vascular cellsin vitro and in the aorta of diabetic micein vivo. Consistently, deficiency in the NRG-1 receptor ErbB4 provokes cellular senescencein vitro as well asin vivo.
Source: Cardiovascular Research - Category: Cardiology Source Type: research