Monthly vitamin D supplementation, pain, and pattern of analgesic prescription: secondary analysis from the randomized, double-blind, placebo-controlled Vitamin D Assessment study

Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to compare the effect of monthly high-dose vitamin D supplementation on a pain impact questionnaire (PIQ-6) score and prescription of analgesics in the general population. We performed a randomized, double-blind, placebo-controlled trial of 5108 community-dwelling participants, aged 50 to 84 years, who were randomly assigned to receive monthly 100,000-IU capsules of vitamin D3 (n = 2558) or placebo (n = 2550) for a median of 3.3 years. The PIQ-6 was administered at baseline, year 1, and final follow-up. Analgesic prescription data were collected from Ministry of Health. There was no difference in mean PIQ-6 score at the end of follow-up (adjusted mean difference: 0.06; P = 0.82) between the vitamin D (n = 2041) and placebo (n = 2014) participants. The proportion of participants dispensed one or more opioids was similar in the vitamin D group (n = 559, 21.9%) compared with placebo (n = 593, 23.3%); the relative risk (RR) adjusted for age, sex, and ethnicity was 0.94 (P = 0.24). Similar results were observed for dispensing of nonsteroidal anti-inflammatory drugs (RR = 0.94; P = 0.24) and other nonopioids (RR = 0.98; P = 0.34). Focusing on vitamin D deficient participants (
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research

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CONCLUSIONS Vitamin D deficiency/insufficiency was associated with risk of osteoporotic thoracolumbar junction vertebral fractures in elderly patients. PMID: 31678984 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
VITAMIN D deficiency can occur if a person is lacking the vitamin, and it ’s important to recognise symptoms of the condition to avoid serious health complications. One sign you may have a vitamin D deficiency is if you feel pain when you press a certain part of the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN D helps regulate the amount of calcium and phosphate in the body. Lacking the vitamin can lead to serious health problems. Studies reveal people may experience pain in a certain part of the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aims to show if vitamin D replacement has an effect on the spinal inhibitory pathways through CSP parameters. Female patients who have CWP with vitamin D deficiency were included. Patients received an 8-week replacement therapy of vitamin D. Patients’ pain were evaluated using the visual analog scale (VAS) and Leeds assessment of neuropathic symptoms and signs pain scale (LANSS). Quality of life with Nottingham Health Profile (NHP) and CSP parameters were also recorded before and after treatment. A total of 51 patients were included in the final analyses. The mean age of the patients was 44.3 ± 12.7...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
VITAMIN D deficiency symptoms may start to show if a person isn ’t getting enough sunlight exposure, and left untreated, serious health complications can occur. One sign to look out for is pain in a certain part of the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: October 2019Source: The Lancet HIV, Volume 6, Issue 10Author(s): Franco Maggiolo, Giuliano Rizzardini, François Raffi, Federico Pulido, Maria Gracia Mateo-Garcia, Jean-Michel Molina, Edmund Ong, Yongwu Shao, David Piontkowsky, Moupali Das, Ian McNicholl, Richard HaubrichSummaryBackgroundTenofovir alafenamide is associated with less renal and bone toxicity than tenofovir disoproxil fumarate and might improve the long-term safety of antiretroviral therapy. We aimed to investigate the effect on bone mineral density of switching from a regimen containing tenofovir disoproxil fumarate to one containing ...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
VITAMIN D deficiency symptoms may occur if a person isn ’t getting enough sunlight exposure for their body to create the vitamin, and left untreated serious health complications can occur. One sign of the condition to be wary of is pain in a certain area of the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
DISCUSSION: Vitamin D deficiency and insufficiency can cause or worsen neck and back pain and muscle spasm. The correction of vitamin D deficiency and insufficiency plays an important role in the treatment of chronic neck and back pain and muscle spasm among patients having concurrent vitamin D deficiency and insufficiency because it can be prevented and treated easily.Given the high health care expenditure on the treatment of chronic neck and back pain, prompt and accurate diagnosis and treatment of vitamin D deficiency and insufficiency not only increase the quality of care but also reduce the cost. PMID: 31496497 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
VITAMIN D is an essential nutrient that helps support the body ’s vital functions. It is well understood that lacking the vitamin can cause serious bone complications. It may come as a surprise that it can also affect a specific area of the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
VITAMIN D is essential for healthy bones, and a lack of the vitamin can cause bones to become soft and weak. It may come as a surprise that it can effect another part of the body.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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