ALS Progression Faster in Hypermetabolic Patients ALS Progression Faster in Hypermetabolic Patients

Patients with amyotrophic lateral sclerosis (ALS) who are hypermetabolic show greater functional decline and shorter survival, according to Australian researchers.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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Publication date: Available online 23 July 2018Source: Sensors and Actuators B: ChemicalAuthor(s): Navid Mohammadian, Farnoush FaridbodAbstractA DNA-hybridization electrochemical biosensor (DNA-HEB) has been developed using a new platform for immobilization of a 20-mer oligonucleotide. In a DNA-HEB, the signal is produced based on hybridization of a probe and its target sequence. DNA-HEB can be a cost-effective techniques be able to be miniaturized. The selected DNA sequence is related to a gene sequence encoding the Cu-Zn superoxide dismutase enzyme (SOD1) which is important in familial Amyotrophic lateral sclerosis (ALS)...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 20 August 2018Source: The Journal of Molecular DiagnosticsAuthor(s): EunRan Suh, Kaitlyn Grando, Vivianna M. Van DeerlinA hexanucleotide GGGGCC repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Accurate determination and quantitation of the repeat length is critical in both clinical and research settings. However, due to the complexity of the C9orf72 expansion with high GC content, large size of repeats, and high rate of insertion/deletions (indels) and sequence variations in the flanking regions, mol...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Neurogastroenterology&Motility, EarlyView.
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Source Type: research
A hexanucleotide GGGGCC repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Accurate determination and quantitation of the repeat length is critical in both clinical and research settings. However, due to the complexity of the C9orf72 expansion with high GC content, large size of repeats, and high rate of insertion/deletions (indels) and sequence variations in the flanking regions, molecular genetic analysis of the locus is challenging.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular Article Source Type: research
Publication date: Available online 19 August 2018Source: NeuroscienceAuthor(s): Alessandra Masala, Simona Sanna, Sonia Esposito, Mauro Rassu, Manuela Galioto, Angelo Zinellu, Ciriaco Carru, Maria Teresa Carrì, Ciro Iaccarino, Claudia CrosioAbstractNeurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS), have been associated to alterations in chromatin structure resulting in long lasting changes in gene expression. ALS is predominantly a sporadic disease and environmental triggers may be involved in its onset. In this respect, alterations in the epigenome can provide the key to transform the geneti...
Source: Neuroscience - Category: Neuroscience Source Type: research
Authors: Barros ANAB, Dourado MET, Pedrosa LFC, Leite-Lais L Abstract Oxidative stress is one of the main mechanisms associated with the pathogenesis of amyotrophic lateral sclerosis (ALS). Copper can affect cellular oxidation and lipid metabolism. The aim of this study was to evaluate the association of copper status with lipid profile and functional status in patients with ALS. A cross-sectional study was carried out including 27 patients with ALS (case group) and 26 healthy individuals (control group). Copper status was evaluated by habitual dietary copper intake, plasma copper, and serum ceruloplasmin concentra...
Source: Journal of Nutrition and Metabolism - Category: Nutrition Tags: J Nutr Metab Source Type: research
Publication date: January 2019Source: Biomedical Signal Processing and Control, Volume 47Author(s): Anil Hazarika, Mausumi Barthakur, Lachit Dutta, Manabendra BhuyanAbstractA support system with efficient learning framework helps eliciting complete knowledge of underlying phenomena of interest. It makes the analysis less-onerous, time-consuming and error-prone and thus promotes large scale applications. Such modeling requires profound understanding of available information and its appropriate utilization. Albeit success of electromyogram (EMG) support systems, challenges still exits specifically in early phase of design ma...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
C9orf72-mediated ALS and FTD: multiple pathways to disease, Published online: 17 August 2018; doi:10.1038/s41582-018-0047-2Repeat expansions in the C9orf72 gene are a frequent cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Balendra and Isaacs review the pathological and mechanistic features of C9orf72-associated ALS and FTD, highlighting loss-of-function, gain-of-function and downstream mechanisms.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
Annals of Neurology, EarlyView.
Source: Annals of Neurology - Category: Neurology Authors: Source Type: research
uiz J Abstract The endocannabinoid system (ECS) exerts a modulatory effect of important functions such as neurotransmission, glial activation, oxidative stress, or protein homeostasis. Dysregulation of these cellular processes is a common neuropathological hallmark in aging and in neurodegenerative diseases of the central nervous system (CNS). The broad spectrum of actions of cannabinoids allows targeting different aspects of these multifactorial diseases. In this review, we examine the therapeutic potential of the ECS for the treatment of chronic neurodegenerative diseases of the CNS focusing on Alzheimer's disea...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
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