In vitro and in vivo activity of contezolid (MRX-I) against Mycobacterium tuberculosis.
In vitro and in vivo activity of contezolid (MRX-I) against Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 2018 May 21;:
Authors: Shoen C, DeStefano M, Hafkin B, Cynamon M
Abstract
The in vitro activity of contezolid (MRX-I) against clinical isolates of M. tuberculosis was evaluated using a microtiter broth dilution assay. MRX-I was as effective in vitro as linezolid (LZD). MRX-I and LZD were subsequently studied in BALB/c mice infected intranasally with M. tuberculosis Erdman. MRX-I and LZD at 100mg/kg significantly reduced the bacterial load in lungs compared to the untreated early and late controls.
PMID: 29784848 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Shoen C, DeStefano M, Hafkin B, Cynamon M Tags: Antimicrob Agents Chemother Source Type: research