Risk factors for near-miss events and safety incidents in pediatric radiation therapy.

CONCLUSIONS: Variances in children occurred in early treatment phases, but were detected at later workflow stages. Quality measures should be implemented during early treatment phases with a focus on younger children and those cared for by cross-covering physicians. PMID: 29776675 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research

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AbstractDiffusing alpha-emitters radiation therapy (DaRT) is the only known method for treating solid tumors with highly destructive alpha radiation. More importantly, as a monotherapy, DaRT has been shown to induce a systemic antitumor immune response following tumor ablation. Here, immunomodulatory strategies to boost the antitumor immune response induced by DaRT, and the response specificity, were investigated in the colon cancer CT26 mouse model. Local treatment prior to DaRT,  with the TLR3 agonist poly I:C, was sufficient to inhibit tumor growth relative to poly I:C or DaRT alone. DaRT used in combination with t...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early- and intermediate-st...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The 7th edition of the TNM classification for esophageal carcinoma is poorly recognized and understood in central and southern China, which might contribute to the relatively low rates of appropriate perioperative procedures applied for esophageal cancer patients.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Cancer;   Palliative Radiotherapy Interventions:   Radiation: Lattice stereotactic body radiation therapy;   Procedure: Peripheral blood Sponsor:   Washington University School of Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14  months after standard therapy with radiation therapy (IR) and temozolomide (TMZ). In a novel mult...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Robotic stereotactic ablative radiotherapy (SABR) is currently under investigation as a noninvasive treatment option for patients with renal cell carcinoma (RCC). For radiation therapy of RCC, tumor motion and...
Source: BMC Urology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Innovations in artificial intelligence (AI) are driving a new industrial revolution, and as a result, the medical radiation sciences is experiencing transformational, open, beneficial, yet disruptive changes. Many studies have already been published on specific frontline examples where AI will improve cancer care, but discussions of how AI will change the medical radiation sciences and its associated professions at the systems level have been comparatively sparse. In this article, the system-level implications of AI on the medical radiation sciences are discussed, and recommendations are made on how professionals in this f...
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Tags: Commentary Source Type: research
Conclusions: altogether, our data suggest that resistance to EGFR inhibition combined with radiotherapy in HNSCC may depend on tumor HIF-2 expression and underline the urgent need to develop novel HIF-2 targeted treatments.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Anal squamous cell carcinoma (ASCC) is the most common histological subtype of anal cancer. Rates have been observed to increase in recent years. Combined chemoradiotherapy (CCRT) is currently the gold standard of treatment. The aim of this study is to assess ASCC prevalence, treatment trends, and overall survival (OS) in the United States.
Source: Journal of Surgical Research - Category: Surgery Authors: Source Type: research
Conclusion: Radiation therapy for nCRT could downstage clinically suspected nodal metastasis. However, such therapy was ineffective when used to treat nodes that were not suspicious for metastasis. Because significant numbers of residual metastases were identified irrespective of coverage by the radiation field, lymphadenectomy should be performed to ensure complete removal of residual nodal metastases after nCRT. PMID: 31624713 [PubMed]
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
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