Naloxone, Naldemedine Best for Opioid Induced Constipation Naloxone, Naldemedine Best for Opioid Induced Constipation

Naloxone is the safest and most effective treatment for opioid-induced constipation (OIC), according to a new review and network meta-analysis published in Gut.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Medscape Today News Source Type: news

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Publication date: Available online 16 November 2018Source: Saudi Journal of Biological SciencesAuthor(s): Yunpeng Luan, Dechang Mao, Aiwei Guo, Yong Cao, Jielong Zhou, Fei Xiang, Zhi XiongAbstractTo verify the laxative effect of Codonopsis bulleyana and its effect on intestinal microbiota, a long-term constipation model was established using 3.0 mg/kg loperamide hydrochloride, after which, the long-term constipation model was administered by 0.2 g/ml high-dose Codonopsis bulleyana water extract. The therapeutic effects were observed by measuring defecation amount and feces moisture content. The composition of intestinal mi...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
(Natural News) As many as one in six children suffer from irritable bowel syndrome (IBS) and its uncomfortable symptoms, including cramps, bloating, diarrhea and constipation. However, it appears that many children with IBS are also deficient in vitamin D. A study published in PLOS ONE revealed that more than 90 percent of children with IBS...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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Source: Experimental Physiology - Category: Physiology Authors: Tags: REVIEW ARTICLE Source Type: research
Publication date: January 2019Source: Biomedicine &Pharmacotherapy, Volume 109Author(s): Deliang Liu, Lei Lin, Yixuan Lin, Yuping Zhong, Shaobao Zhang, Wen Liu, Baorong Zou, Qiongfeng Liao, Zhiyong XieAbstractZengye decoction (ZYD), a traditional Chinese medicinal formula, has been used in the treatment of various chronic diseases, such as constipation and skin dryness syndrome. Clinically, the specific mechanisms and targets of ZYD for treating disease remain unclear. The present study was undertaken to investigate the effects of ZYD on the gut microbiota and host metabolites in aged constipated rats and the relations...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
This study investigates the effect of major earthquakes on patients with PD. The participants were outpatients with PD from hospitals located in areas heavily damaged by the earthquakes. We performed an anonymous survey at nine medical institutions to investigate the condition of these patients during the month following the earthquakes. We collected questionnaires from 335 patients with PD. The mean age was 72.6, and the mean disease duration was 7.4 years. Regarding physical conditions, 29.3% of the patients worsened, 1.5% improved, and 68.1% had no change. The mental health of 35.2% of the patients worsened, 2.4% impr...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractThe Peristeen transanal irrigation system is intended to allow people with bowel dysfunction to flush out the lower part of the bowel as part of their bowel management strategy. Peristeen was the subject of an evaluation by the National Institute for Health and Care Excellence, through its Medical Technologies Evaluation Programme, for the management of bowel dysfunction. The company, Coloplast, submitted a case for adoption of the technology, claiming that the technology improves the severity of chronic constipation or faecal incontinence and improves quality of life for people with bowel dysfunction. Other claime...
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
This study suggested that MHGG treatment could elicit constipation relief in mice.Practical applicationsIn this study, partially hydrolyzed guar gum (PHGG) produced by mannanase hydrolysis was applied for the relieving constipation in mice. The medium ‐molecular‐weight product (Mw 2,000–10,000 Da) could elicit constipation relief and modulate the gut microbiota in mice, which shows the potential to act as dietary fiber for constipation treatment.
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: FULL ARTICLE Source Type: research
Conclusions&InferencesThe clinical diagnosis of RED in patients with CC is achieved with combination of DRE, HRM and an optimized, time ‐based BET. Prospective studies are necessary to confirm the proposed 22 second cutoff for tbBET.
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractPlecanatide (Trulance®), a guanylate cyclase  C agonist, is an effective and generally well-tolerated treatment option for adults with chronic idiopathic constipation or irritable bowel syndrome with constipation. It can be administered with or without food, at any time of the day. In phase 3 clinical trials, once-daily plecanatide 3 mg sig nificantly improved stool frequency, stool consistency, clinical symptoms (e.g. straining, abdominal symptoms including pain), health-related quality of life, and treatment satisfaction. Plecanatide is generally well tolerated, with most adverse events being o...
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
AbstractPurposeSevere constipation and encopresis are significant problems in the pediatric population. Medical management succeeds in 50 –70%; however, surgical considerations are necessary for the remainder such as the antegrade continence enema (ACE). The purpose of this study is to assess the long-term outcomes following the ACE procedure.MethodsAll patients undergoing an ACE over a 14-year period were included. Data on clinical conditions, treatments, and outcomes were collected. A successful outcome was defined as remaining clean with ≤ 1 accident per week. Comparative data were analyzed using the Fis...
Source: Pediatric Surgery International - Category: Surgery Source Type: research
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