New 'light therapy' could treat constipation better than drugs

Scientists in Australia and at Washington University discovered that they could quickly cure constipation in mice that they had genetically engineered to have neurons that 'move' in response to blue light.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Feeding problems due to sensory sensitivities common in children with constipation
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Gastroenterology, Neurology, Pediatrics, Psychiatry, Journal, Source Type: news
Abstract Background: Constipation is an intestinal syndrome that can be created alone or in the context of another disease in patients admitted to intensive care units (ICUs). Given the role of sennosides in increasing the transfer rate of materials from the large intestine, we aimed to compare the effect of senalin with bisacodyl on the treatment of constipation in patients admitted to ICUs. Materials and Methods: In this randomized, double-blind study, 70 patients admitted to the ICU were divided into two groups. The senalin recipient group received senalin with a dose of 500 mg daily for 3 days. The bisaco...
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
Publication date: Available online 17 April 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Anthony F. Domenichiello, Christopher E. RamsdenAbstractChronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are un...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
THURSDAY, April 18, 2019 -- Children with chronic constipation have underlying sensory characteristics that contribute to toileting behavioral difficulties, according to a study published online April 18 in The Journal of Pediatrics. Lauren M....
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Care of children with chronic constipation should include consideration of sensory issues and possible referral to occupational therapy, according to US researchers, who claim their findings are “revolutionary”.
Source: Nursing Times - Category: Nursing Source Type: news
(Ann&Robert H. Lurie Children's Hospital of Chicago) In the first study of its kind in the US, researchers found that normally developing preschool children with chronic constipation have underlying sensory issues that contribute to their difficulties with toileting behaviors. These children are often picky eaters who might be overly sensitive to food textures, tastes, or odors. They also might have an exaggerated response to noises, bright lights, or other sensory stimuli. Findings were published in the Journal of Pediatrics.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
To assess differences in sensory processing patterns between children with chronic constipation compared with a matched normative sample as well as to examine the extent to which specific sensory processing patterns and modality scores predicted atypical toileting behaviors.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research
Updated Date: Apr 17, 2019 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
This study highlights how the use of in vitro 3D model can allow rapid screening and selection of new and safer drugs. Introduction Angiogenesis is a complex and finely regulated process that consists of the growth of new capillary blood vessels from pre-existing vessels to create communication pathways among tissues. The coordination of different activities such as endothelial cell proliferation and migration, metalloproteinase function, integrin expression and pericyte stabilization is essential for angiogenesis (Folkman, 1984). The “angiogenic switch” is “on” when the balance between pro-...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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