Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells

The host factors that promote the survival and persistence of HIV-infected CD4+ T  cells are not clear. Kuo et al. demonstrate that the anti-apoptotic protein BIRC5 and its upstream regulator OX40 can promote survival of HIV-1-infected reservoir CD4+ T cells, specifically during clonal proliferation. These findings point to clinical strategies that may reduce persisting viral reservoirs.

Source: Immunity - May 22, 2018 Category: Allergy & Immunology Authors: Hsiao-Hsuan Kuo, Rushdy Ahmad, Guinevere Q. Lee, Ce Gao, Hsiao-Rong Chen, Zhengyu Ouyang, Matthew J. Szucs, Dhohyung Kim, Athe Tsibris, Tae-Wook Chun, Emilie Battivelli, Eric Verdin, Eric S. Rosenberg, Steven A. Carr, Xu G. Yu, Mathias Lichterfeld Tags: Article Source Type: research