Nurse Dies After Contracting Rare Nipah Virus While Treating Outbreak in India

(NEW DELHI) — The nurse, with two young children and a husband working overseas, scrawled the words in blue pen as she lay dying in an Indian hospital isolation ward, sick with a rare and deadly virus. “I think I am almost on my way. I may not be able to see you again. Sorry,” Lini Puthusheri wrote her husband in a tangle of English and Malayalam, the main language of the south Indian state of Kerala. “Take care of our children,” wrote Puthusheri, who was infected with Nipah virus while caring for sick patients. She signed it “Lots of love.” She died Monday. At least 10 people have died of Nipah since an outbreak began earlier this month in Kerala, health officials say, and two more people are in critical condition. There is no vaccine for the virus, which can cause raging fevers, convulsions and vomiting, and kills up to 75 percent of people who come down with it. The only treatment is supportive care to keep patients comfortable. At least eight people who have had contact with the sick are being kept in isolation, in their homes, so their conditions can be monitored, officials say. Nipah can be spread by fruit bats, pigs and through human-to-human contact. Officials suspect the Kerala outbreak may have begun with bats. Kerala state health minister K.K. Shylaja told reporters Tuesday that there had been no new cases of Nipah, though it was not immediately clear when the last case was reported. Puthusheri treated one of the first N...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized India onetime Source Type: news

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Nipah virus is an emerging pathogenic paramyxovirus responsible for sporadic and isolated outbreaks of severe respiratory and neurologic disease in Southern Asia. As a zoonotic virus, disease can manifest in both animals and human with indigenous fruit bats acting as natural reservoirs of the virus. The effects of viral infection vary from acute respiratory distress to fatal encephalitis. There are currently no approved therapeutics or vaccines against the virus, and growing concerns that this highly pathogenic infection has the potential to cause larger epidemics capable of inflicting significant mortality burden.Like the...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
by Neeltje van Doremalen, Teresa Lambe, Sarah Sebastian, Trenton Bushmaker, Robert Fischer, Friederike Feldmann, Elaine Haddock, Michael Letko, Victoria A. Avanzato, Ilona Rissanen, Rachel LaCasse, Dana Scott, Thomas A. Bowden, Sarah Gilbert, Vincent Munster Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted i...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Authors: Singh RK, Dhama K, Chakraborty S, Tiwari R, Natesan S, Khandia R, Munjal A, Vora KS, Latheef SK, Karthik K, Singh Malik Y, Singh R, Chaicumpa W, Mourya DT Abstract Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. The disease was reported for the first time from the Kampung Sungai Nipah village of Malaysia in 1998. Human-to-human transmission also occu...
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
Publication date: Available online 26 February 2019Source: Microbes and InfectionAuthor(s): Nazia Thakur, Dalan BaileyAbstractNipah virus is an emerging zoonotic paramyxovirus that causes severe and often fatal respiratory and neurological disease in humans. The virus was first discovered after an outbreak of encephalitis in pig farmers in Malaysia and Singapore with subsequent outbreaks in Bangladesh or India occurring almost annually. Due to the highly pathogenic nature of NiV, its pandemic potential, and the lack of licensed vaccines or therapeutics, there is a requirement for research and development into highly sensit...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Purpose: Nipah virus (NiV), a paramyxovirus, causes febrile encephalitis and severe respiratory disease in humans and animals. Nipah virus outbreaks have been reported from Malaysia, Bangladesh, India and Singapore. The case positive in humans have been attributed to zoonotic transmission from pigs and bats, human-to-human transmission, and eating fruits or juices contaminated with bat secretions. At present no vaccines or drugs are available for those infected with NiV. Fruit bats of family Pteropodidae have been identified as the reservoir for NiV.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 20.066 Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
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Abstract We briefly review the situations arising out of epidemics that erupt rather suddenly, threatening life and livelihoods of humans. Ebola, Zika and the Nipah virus outbreaks are recent examples where the viral epidemics have led to considerably high degree of fatalities or debilitating consequences. The problems are accentuated by a lack of drugs or vaccines against the new and emergent viruses, and the inordinate amount of temporal and financial resources that are required to combat the novel pathogen. Progress in computational. biological and informational sciences have made it possible to consider design...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Persistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. With little knowledge of its molecular mechanisms, we utilized the proteome data of NiV to evaluate the potency of three major proteins (phosphoprotein, polymerase, and nucleocapsid protein RdRp complex) to count as a possible candidate for epitope ‐based vaccine design. AbstractPersistent outbreaks of Nipah virus (NiV) with severe case fatality throw a major challenge on researchers to develop a drug or vaccine to combat the disease. With little knowledge of its m...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt;&amp;lt;span […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology date palm sap henipavirus Nipah virus outbreak Papua New Guinea poliovirus Smithsonian Institution vaccine viral viruses Source Type: blogs
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